Foundayo is the brand name for orforglipron, a once daily weight loss tablet developed by Eli Lilly, the same company behind Mounjaro.
The Medicines and Healthcare products Regulatory Agency (MHRA) has authorised orforglipron (Foundayo), making the UK the first country in Europe to approve this GLP-1 tablet for weight management and type 2 diabetes.
Foundayo consultations are provided by our qualified private GPs at GP Matters. Treatment is prescribed only following an individual medical assessment and where clinically appropriate.
Everyone starts on the lowest dose. Your prescriber increases it in steps, and each step needs at least 30 days on the dose before it.
Initial consultation (new patients) - £150
Follow up consultations (if required) - £100
Foundayo is a prescription-only, once-daily weight loss tablet that contains orforglipron, a glucagon-like peptide-1 (GLP-1) receptor agonist. Foundayo is an oral pill that is swallowed whole at any time of day that is convenient for you. It is made by Eli Lilly, the same manufacturer as Mounjaro.
Foundayo can be taken with or without food and does not require fasting before or after taking the tablet.
Foundayo’s active ingredient, orforglipron , works by binding to the GLP-1 receptors in the brain to mimic the effects of the naturally occurring hormone, GLP-1. So, Foundayo works to help you lose weight by:
- reducing your appetite
- slowing the time it takes for food to pass through the stomach
- regulating your blood sugar levels
These effects can reduce appetite and help you feel fuller for longer. Together, this makes it easier for you to stick to a diet and exercise plan, which you will need to do to get the full benefit of Foundayo.
Foundayo is taken alongside a reduced-calorie diet and exercise plan, and is suitable for adults aged 18 and older with a body mass index (BMI) of:
- 30 or more
- 27 to 30 with at least one weight-related health condition, such as prediabetes, type 2 diabetes, high blood pressure, or obstructive sleep apnoea
Foundayo may not be suitable for everyone because certain health conditions or medications can interact with Foundayo and can make it less effective or potentially unsafe.
Do not take Foundayo if you are:
allergic to orforglipron or any other ingredients listed in the medication
pregnant or breastfeeding
Before taking Foundayo, let the doctor know if you:
- have or have ever had pancreatitis
- are using a sulfonylurea and/or insulin for diabetes
- have severe problems with food digestion or food staying in your stomach for longer than usual (severe gastroparesis)
- you have kidney problems because some Foundayo side effects, like feeling and being sick and diarrhoea, can cause dehydration
- are taking medication to manage high blood pressure
- have gallbladder problems
- have a problem with your eyes or vision
- are due to have surgery and require anaesthesia
- have or have had severe heart failure
Adults on the highest approved Foundayo dose lost around 11% of body weight on average over 72 weeks. The figure comes from the ATTAIN-1 clinical trial.
In a 72-week study of adults without diabetes, average weight loss was:
2.1% (5.3 lbs) for placebo.
7.4% (17.2 lbs) for 5.5 mg
8.3% (18.9 lbs) for 9 mg
11.1% (24.9 lbs) for 17.2 mg
In a 72-week study of adults with type 2 diabetes, average weight loss was:
2.5% (5.9 lbs) for placebo
5.1% (11.7 lbs) for 5.5 mg
7% (15.9 lbs) for 9 mg
9.6% (21.2 lbs) for 17.2 mg
Individual results may vary / Along with diet and exercise.
See further info
Foundayo is a once daily pill. You can take your daily dose at any time of the day, whenever is most convenient for you, with or without food. You should swallow the tablet whole, with some water if needed, but do not break, crush, or chew the tablet or take more than 1 pill per day.
Because Foundayo does not require special coatings to protect it from stomach acid and enhance its absorption into the bloodstream, like some other GLP-1 pills, it does not have any fasting restrictions you must follow before taking it. This makes taking Foundayo easier and more flexible for some people.
Foundayo pills are available in 6 dosages. You’ll begin with 0.8 mg once daily. After at least 30 days, your doctor may increase the dose depending on how you respond to treatment and how well you tolerate it.
The available Foundayo doses are:
Month 1 (starting dose) – 0.8mg
Month 2 – 2.5mg
Month 3 – 5.5mg
Month 4 – 9mg
Month 5 – 14.5mg
Month 6 (maximum dose) – 17.2mg
You may not need to take the maximum Foundayo dose. Your doctor will monitor how your body responds to orforglipron, whether you get any side effects, and consider your weight loss goals to help you find the lowest effective dose.
After taking Foundayo 0.8mg once daily for at least 30 days, the next dose is:
Foundayo 2.5mg once daily.
After at least another 30 days on 2.5mg, the dose may be increased to 5.5mg once daily.
From this point, further increases to 9mg, 14.5mg and 17.2mg are based on:
how well Foundayo is working
your appetite and weight response
how well you tolerate the medicine
whether you are experiencing side effects
your prescriber’s clinical judgement
There is therefore no requirement for every patient to progress all the way to 17.2mg.
Foundayo is intended to be a long-term weight loss treatment, with clinical trial participants taking it for at least 72 weeks. Your doctor will advise how long you may need to continue taking Foundayo for.
If you forget to take a Foundayo dose, take it as soon as you remember, but do not take more than one tablet per day. You should not take a double dose to make up for a forgotten dose.
If you miss 7 or more Foundayo pills in a row, speak to your doctor because you will need to restart your schedule at a lower dose to reduce the chance of side effects. Your doctor will advise you how to do this safely.
Taking too much Foundayo can make you feel sick or be sick. You must contact your doctor immediately for advice if you have taken too many Foundayo pills.
You should not stop taking Foundayo without talking to your doctor first. If treatment is stopped, appetite may return and weight may be regained. If you have type 2 diabetes, stopping Foundayo may also cause your blood glucose levels to increase.
Your doctor can advise you on whether treatment should be stopped and the most appropriate way to manage your weight afterwards.
Yes, you can usually drink alcohol in moderation on Foundayo as there is no known interaction. However, it is best to avoid or limit your intake because alcohol can worsen or cause gastrointestinal side effects, such as feeling or being sick, or diarrhoea. It can also impact your blood sugar levels and contribute to your daily calorie intake without you realising.
It is common to still feel hungry on Foundayo, especially in the first few weeks when you are taking a lower dose to allow your body to get used to the medication and minimise the chance of side effects. The active ingredient, orforglipron, works gradually over time to regulate your appetite, so it can take several months for you to notice the full effects.
Foundayo also does not work on its own, so you will need to stick to a reduced calorie diet and commit to being more active. If you have not made adjustments to your lifestyle and are still feeling hungry, this may also be a reason why you’re not seeing the results you expected on Foundayo.
You can find a full list of side effects in the Foundayo patient information leaflet.
No, Foundayo is not available over the counter. You must have a valid prescription from a registered healthcare professional who will check to make sure Foundayo is safe and suitable for you.
Foundayo is a prescription-only medication, which means you must have a doctor’s approval to get it.